Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae.
نویسندگان
چکیده
Miltiradiene (1) is the precursor of phenolic diterpenoids such as ferruginol (2), requiring aromatization and hydroxylation. While this has been attributed to a single cytochrome P450 (CYP76AH1), characterization of the rosemary ortholog CYP76AH4 led to the discovery that these CYPs simply hydroxylate the facilely oxidized aromatic intermediate abietatriene (3).
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 11 44 شماره
صفحات -
تاریخ انتشار 2013